Wounds were serially assessed on post-burn days 3, 7, 14, 21, and 28.
#Does silver sulfadiazine cream expire skin
The 5 randomized OTS therapies were: irradiated sterile human skin allograft (IHS), biodegradable temporizing matrix (BTM), polylactic acid skin substitute, hyaluronic acid ester matrix (HAM), and decellularized fish skin graft (FSG). The remaining 6 burns were treated with 1% silver sulfadiazine cream (Ascend Laboratories, LLC, Parsippany, NJ) as the PFC standard of care (SOC) controls. Animals were then randomized into 5 experimental groups, and OTS therapies were applied to 6 of the 12 created DPT burns. Nonsurgical debridement was done 1-hour after burn creation using sterile saline water and gauze to remove excess eschar tissue. Very rare (less than 0.Deep partial-thickness (DPT) burns (25 cm 2) were created on the dorsum of 5 anesthetized pigs utilizing a thermocouple burn device at 100☌ for 15 seconds. Hematologicįrequency not reported: Neutrophil count decreased, white blood cell depression, agranulocytosis, aplastic anemia, thrombocytopenia, hemolytic anemia DermatologicĬommon (1% to 10%): Pruritus, application site rash, eczema, contact dermatitisįrequency not reported: Skin necrosis, erythema multiforme, skin discoloration, burning sensation, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis Renal
GeneralĪbsorption varies depending upon the percent of body surface area being treated and extent of tissue damage it is possible any adverse reaction associated with sulfonamides may occur.
#Does silver sulfadiazine cream expire professional
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Ĭheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Incidence not knownĪpplies to silver sulfadiazine topical: compounding powder, topical cream. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of silver sulfadiazine topical may occur that usually do not need medical attention.
sores, ulcers, or white spots in the mouth or on the lips.red skin lesions, often with a purple center.increased sensitivity of the skin to sunlight, especially in patients with burns on large areas.blistering, peeling, or loosening of the skin.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor as soon as possible if any of the following side effects occur while taking silver sulfadiazine topical: Incidence not known Serious side effects of SilvadeneĪlong with its needed effects, silver sulfadiazine topical (the active ingredient contained in Silvadene) may cause some unwanted effects. Some dosage forms listed on this page may not apply to the brand name Silvadene.Īpplies to silver sulfadiazine topical: topical cream. Note: This document contains side effect information about silver sulfadiazine topical. Generic name: silver sulfadiazine topical
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